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Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells

Abstract Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide, and few effective therapeutics are available. Osthole (OST), a natural coumarin, has been proven to be a potential anticancer compound. In this study, we found that OST significantly inhibited PC growth both in vit...

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Principais autores: Ningna Weng, Sujuan Lv, Hong Chen, Hanchen Zheng, Tong Lin, Qing Zhu, Kai Zhu, Sha Huang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2024-12-01
coleção:Scientific Reports
Assuntos:
Osthole
Pancreatic cancer
Autophagy
ATF3
mTOR
Acesso em linha:https://doi.org/10.1038/s41598-024-81911-z
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