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Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis in Vitro and in Vivo

Lung cancer is a leading cause of cancer-related deaths worldwide. NOTCH3 signaling is mainly expressed in non-small cell lung carcinoma (NSCLC), and has been proposed as a therapeutic target of NSCLC. While, few agents for preventing or treating NSCLC via targeting NOTCH3 signaling are used in mode...

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Main Authors: Tao Su, Xia Yang, Jian-Hua Deng, Qiu-Ju Huang, Su-Chao Huang, Yan-Min Zhang, Hong-Ming Zheng, Ying Wang, Lin-Lin Lu, Zhong-Qiu Liu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
evodiamine
lung cancer
Notch3
NOTCH3 methylation
DNA methyltransferases
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00434/full
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