Recurrent NR3C1 Aberrations at First Diagnosis Relate to Steroid Resistance in Pediatric T-Cell Acute Lymphoblastic Leukemia Patients

The glucocorticoid receptor NR3C1 is essential for steroid-induced apoptosis, and deletions of this gene have been recurrently identified at disease relapse for acute lymphoblastic leukemia (ALL) patients. Here, we demonstrate that recurrent NR3C1 inactivating aberrations—including deletions, missen...

Полное описание

Библиографические подробности

Главные авторы:	Jordy C. G. van der Zwet, Willem Smits, Jessica G. C. A. M. Buijs-Gladdines, Rob Pieters, Jules P. P. Meijerink
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2021-01-01
Серии:	HemaSphere
Online-ссылка:	http://journals.lww.com/10.1097/HS9.0000000000000513
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!