RhoA/ROCK Pathway Is Upregulated in Experimental Autoimmune Myocarditis and Is Inhibited by Simvastatin at the Stage of Myosin Light Chain Phosphorylation

Many studies have proven the involvement of the RhoA/ROCK pathway in autoimmune and cardiovascular diseases and the beneficial effects of its downregulation. Here, we examined whether the effect of simvastatin on experimental autoimmune myocarditis (EAM) may be through targeting the Ras homolog fami...

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Hlavní autoři:	Monika Skrzypiec-Spring, Maciej Kaczorowski, Alina Rak-Pasikowska, Agnieszka Sapa-Wojciechowska, Krzysztof Kujawa, Agnieszka Żuryń, Iwona Bil-Lula, Agnieszka Hałoń, Adam Szeląg
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2024-03-01
Edice:	Biomedicines
Témata:	immune system myocarditis molecular pathology RhoA/ROCK pathway simvastatin metalloproteinases
On-line přístup:	https://www.mdpi.com/2227-9059/12/3/596
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