A laboratory-based predictive pathway for the development of Neisseria gonorrhoeae high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase

ABSTRACT The continued emergence of Neisseria gonorrhoeae strains that express resistance to multiple antibiotics, including the last drug for empiric monotherapy (ceftriaxone), necessitates the development of new treatment options to cure gonorrheal infections. Toward this goal, we recently reporte...

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Hauptverfasser:	Jacqueline T. Balthazar, Daniel Golparian, Magnus Unemo, Timothy D. Read, Miriam Grosse, Marc Stadler, Kenneth Pfarr, Andrea Schiefer, Achim Hoerauf, Jennifer L. Edwards, Dmitry G. Vassylyev, William M. Shafer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2024-06-01
Schriftenreihe:	Microbiology Spectrum
Schlagworte:	Neisseria gonorrhoeae corallopyronin A resistance RNAP RpoB/RpoC
Online-Zugang:	https://journals.asm.org/doi/10.1128/spectrum.00560-24
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