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Heterogeneity of Metabolic Vulnerability in Imatinib-Resistant Gastrointestinal Stromal Tumor

Metabolic reprogramming is a hallmark of cancer cells in response to targeted therapy. Decreased glycolytic activity with enhanced mitochondrial respiration secondary to imatinib has been shown in imatinib-sensitive gastrointestional stromal tumors (GIST). However, the role of energy metabolism in i...

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Main Authors: Wen-Kuan Huang, Jiwei Gao, Ziqing Chen, Hao Shi, Juan Yuan, Huanhuan L. Cui, Chun-Nan Yeh, Robert Bränström, Catharina Larsson, Shuijie Li, Weng-Onn Lui
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
gastrointestinal stromal tumor
energy metabolism
mitochondrial biogenesis
imatinib resistance
Online Access:https://www.mdpi.com/2073-4409/9/6/1333
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