The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

Abstract Background In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated area of OA cartilage. However, to date, it is not known why chondrocyte an...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Nobuho Tanaka, Hirotaka Tsuno, Satoru Ohashi, Mitsuyasu Iwasawa, Hiroshi Furukawa, Tomohiro Kato, Naoshi Fukui
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2021-02-01
Serie:	BMC Musculoskeletal Disorders
Soggetti:	Osteoarthritis Chondrocyte Matrix synthesis Laser capture microdissection IGF IGF1R
Accesso online:	https://doi.org/10.1186/s12891-021-04096-w
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!