Hematopoietic Stem Cell Transplantation and Vasculopathy Associated With STAT3-Dominant-Negative Hyper-IgE Syndrome

Dominant negative mutations in the transcription-factor STAT3 underlie the rare primary immunodeficiency Job's syndrome. Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) has shown promise in correction of the underlying immunological defect, with one report suggesting HSCT can prevent devel...

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Detalhes bibliográficos

Principais autores:	Mark J. Ponsford, James Clark, Joel Mock, Mario Abinun, Emily Carne, Tariq El-Shanawany, Paul E. Williams, Anirban Choudhury, Alexandra F. Freeman, Andrew R. Gennery, Stephen Jolles
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-09-01
coleção:	Frontiers in Pediatrics
Assuntos:	Job's syndrome STAT3 transcription factor ST elevation myocardial infarction coronary vessels thrombosis cardiovascular diseases
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fped.2020.00575/full
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