Functional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity

Abstract Linkage-specific ubiquitin chains govern the outcome of numerous critical ubiquitin-dependent signaling processes, but their targets and functional impacts remain incompletely understood due to a paucity of tools for their specific detection and manipulation. Here, we applied a cell-based u...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Javier Arroyo-Gomez, Matthew J Murray, Claire Guérillon, Juanjuan Wang, Ekaterina Isaakova, Nazaret Reverón-Gómez, Mikaela Koutrouli, Aldwin Suryo Rahmanto, Katrine Mitrofanov, Andreas Ingham, Sofie Schovsbo, Katrine Weischenfeldt, Fabian Coscia, Dimitris Typas, Moritz Völker-Albert, Victor Solis, Lars Juhl Jensen, Anja Groth, Andreas Mund, Petra Beli, Robert F Shearer, Niels Mailand
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2025-10-01
coleção:	The EMBO Journal
Assuntos:	Ubiquitin Linkage-specific ubiquitylation Ubiquitin-dependent proteolysis Epigenome maintenance Heterochromatin
Acesso em linha:	https://doi.org/10.1038/s44318-025-00599-7
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!