Is It Possible to Separate the Graft-Versus-Leukemia (GVL) Effect Against B Cell Acute Lymphoblastic Leukemia From Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplant?

Hematopoietic cell transplant is a curative therapy for many pediatric patients with high risk acute lymphoblastic leukemia. Its therapeutic mechanism is primarily based on the generation of an alloreactive graft-versus-leukemia effect that can eliminate residual leukemia cells thus preventing relap...

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Auteurs principaux:	Jacob Rozmus, Sima T. Bhatt, Nataliya Prokopenko Buxbaum, Geoffrey D. E. Cuvelier, Amanda M. Li, Carrie L. Kitko, Kirk R. Schultz
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2022-03-01
Collection:	Frontiers in Pediatrics
Sujets:	pediatric B-ALL graft-versus-leukemia graft-versus-host disease relapse hematopoietic cell transplantation
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fped.2022.796994/full
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