APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma

APOBEC is a mutagenic source in human papillomavirus (HPV)-mediated malignancies, including HPV+ oropharyngeal squamous cell carcinoma (HPV + OPSCC), and in HPV genomes. It is unknown why APOBEC mutations predominate in HPV + OPSCC, or if the APOBEC-induced mutations observed in both human cancers a...

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Главные авторы:	Daniel L. Faden, Krystle A. Lang Kuhs, Maoxuan Lin, Adam Langenbucher, Maisa Pinheiro, Meredith Yeager, Michael Cullen, Joseph F. Boland, Mia Steinberg, Sara Bass, James S. Lewis, Michael S. Lawrence, Robert L. Ferris, Lisa Mirabello
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2021-08-01
Серии:	Viruses
Предметы:	APOBEC HPV Humanpapilloma virus oropharyngeal cancer oropharyngeal squamous cell carcinoma
Online-ссылка:	https://www.mdpi.com/1999-4915/13/8/1666
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