Glycolysis-driven cancer-associated fibroblasts shape T-Cell exclusion via the CXCL16–CXCR6 Axis: a metabolic-chemokine mechanism in tumor immunity

Abstract Background Immune-excluded tumors are characterized by abundant CD8+ T cells at the invasive margin but scarce infiltration within tumor nests, leading to limited responses to immunotherapy. Emerging evidence identifies cancer-associated fibroblasts (CAFs) as key mediators of immune exclusi...

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Autori principali:	Yunya Liu, Chutong Xiong, Guichen Huang, Menghao Xu, JinXiao Li, Minfeng Zhou, Fengxia Liang, Rui Chen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-05-01
Serie:	Journal of Translational Medicine
Soggetti:	Immune exclusion Combined immunotherapy for Cancer Cancer-associated fibroblasts GlyCAF GLUT1 CXCL16
Accesso online:	https://doi.org/10.1186/s12967-026-08160-8
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