Expression of G2019S LRRK2 in Rat Primary Astrocytes Mediates Neurotoxicity and Alters the Dopamine Synthesis Pathway in N27 Cells via Astrocytic Proinflammatory Cytokines and Neurotrophic Factors

Astrocytes in the brain contribute to various essential functions, including maintenance of the neuronal framework, survival, communication, metabolic processes, and neurotransmitter levels. Leucine-rich repeat kinase 2 (LRRK2) is associated with the pathogenesis of Parkinson’s disease (PD). LRRK2 i...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Dong Hwan Ho, Hyejung Kim, Daleum Nam, Mi Kyoung Seo, Sung Woo Park, Ilhong Son
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-05-01
coleção:	Current Issues in Molecular Biology
Assuntos:	Parkinson’s disease leucine-rich repeat kinase 2 (LRRK2) astrocyte neurotrophic factor neuroinflammation dopamine synthesis pathway
Acesso em linha:	https://www.mdpi.com/1467-3045/46/5/263
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!