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Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against <i>Clostridioides difficile</i>

Mucosal vaccination aims to prevent infection mainly by inducing secretory IgA (sIgA) antibody, which neutralises pathogens and enterotoxins by blocking their attachment to epithelial cells. We previously demonstrated that encapsulated protein antigen CD0873 given orally to hamsters induces neutrali...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Cansu Karyal, Panayiota Palazi, Jaime Hughes, Rhys C. Griffiths, Ruby R. Persaud, Patrick J. Tighe, Nicholas J. Mitchell, Ruth Griffin
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-12-01
Schriftenreihe:Vaccines
Schlagworte:
oral vaccine
<i>Clostridioides difficile</i>
recombinant protein
sIgA
IgG
lipidation
Online-Zugang:https://www.mdpi.com/2076-393X/9/12/1453
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