HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3

Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disease caused by polyglutamine-expanded ataxin-3. Previously, we prepared a SCA3 animal model by generating transgenic mice expressing disease-causing ataxin-3-Q79. Mutant ataxin-3-Q79 caused cerebellar malfunction of S...

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Principais autores:	An-Hsun Chou, Si-Ying Chen, Tu-Hsueh Yeh, Yi-Hsin Weng, Hung-Li Wang
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2011-02-01
叢編:	Neurobiology of Disease
主題:	Spinocerebellar ataxia type 3 Ataxin-3 Polyglutamine-expanded ataxin-3 SCA3 transgenic mice Cerebellum Histone deacetylase
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S0969996110003530
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