Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles

Abstract Sarcopenia is an age-related condition characterized by loss of skeletal muscle mass and strength and is associated with increased cancer incidence and mortality, yet how muscle decline promotes tumorigenesis remains unclear. Here, we show that skeletal muscle functions as an anti-tumor org...

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Hlavní autoři:	Kah Yong Goh, Wen Xing Lee, Qian Gou, Sze Mun Choy, Shi Chee Ong, Priya D. Gopal Krishnan, Huaxin Wang, Lewin Raymarc Roldan Turqueza, Qian Hui Tan, Kenon Chua, Shang Li, Jun Nishiyama, Nathan Harmston, Hong-Wen Tang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-04-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-026-72410-y
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