Organoid-guided evidence that umbilical cord MSC-derived extracellular vesicles restore alveolar repair in cigarette smoke-induced lung injury

Chronic cigarette smoke (CS) disrupts epithelial homeostasis, fuels persistent inflammation, and impairs alveolar repair—hallmarks of COPD with few disease-modifying options. Extracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUC-MSCs) are emerging as cell-free modulators...

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Principais autores:	Syahidatulamali Che Shaffi, Anan A. Ishtiah, Azim Patar, Badrul Hisham Yahaya
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Series:	Frontiers in Cell and Developmental Biology
Assuntos:	alveolar regeneration cigarette smoke (CS) extracellular vesicles lung organoids umbilical cord mesenchymal stem cells
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1710021/full
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