CCA-addition in the cold: Structural characterization of the psychrophilic CCA-adding enzyme from the permafrost bacterium Planococcus halocryophilus

CCA-adding enzymes are highly specific RNA polymerases that add and maintain the sequence C-C-A at tRNA 3‘-ends. Recently, we could reveal that cold adaptation of such a polymerase is not only achieved at the expense of enzyme stability, but also at the cost of polymerization fidelity. Enzymes from...

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Główni autorzy:	Raphaël de Wijn, Kévin Rollet, Felix G.M. Ernst, Karolin Wellner, Heike Betat, Mario Mörl, Claude Sauter
Format:	Artigo
Język:	Inglês
Wydane:	American Association for the Advancement of Science (AAAS) 2021-01-01
Seria:	Computational and Structural Biotechnology Journal
Hasła przedmiotowe:	CCA-adding enzyme tRNA Cold adaptation Psychrophilic protein X-ray crystallography SAXS
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S2001037021004402
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