Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

Abstract The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are unknown. To address this knowledge gap, we developed a mouse model to simulate male-to-female transition in human adolescents in whom puberty is first arre...

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Hlavní autoři:	Tian Nie, Varun S. Venkatesh, Suzanne Golub, Kathryn S. Stok, Haniyeh Hemmatian, Reena Desai, David J. Handelsman, Jeffrey D. Zajac, Mathis Grossmann, Rachel A. Davey
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2024-01-01
Edice:	Bone Research
On-line přístup:	https://doi.org/10.1038/s41413-023-00308-2
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