CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element

Epigenetic states that are established during thymic T cell development influence functionality of mature T cells. Authors here show that early developmental programming of the Cd4 locus is comprised of DNA-demethylation at a specific stimulus-responsive element, which allows long-term maintenance o...

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Hlavní autoři:	Athmane Teghanemt, Priyanjali Pulipati, Kara Misel-Wuchter, Kenneth Day, Matthew S. Yorek, Ren Yi, Henry L. Keen, Christy Au, Thorsten Maretzky, Prajwal Gurung, Dan R. Littman, Priya D. Issuree
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2022-03-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-022-28914-4
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