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Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how the functions of the multiple domains of Munc13–1 are coordinated. The crystal structure of a Munc13–1 fragment including it...

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Principais autores: Junjie Xu, Marcial Camacho, Yibin Xu, Victoria Esser, Xiaoxia Liu, Thorsten Trimbuch, Yun-Zu Pan, Cong Ma, Diana R Tomchick, Christian Rosenmund, Josep Rizo
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2017-02-01
Serier:eLife
Fag:
neurotransmitter release
Munc13
presynaptic plasticity
synaptic vesicle fusion
calcium binding
Online adgang:https://elifesciences.org/articles/22567
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