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Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription

Abstract Background Epigenetic dysregulation is essential to the tumorigenesis of oral squamous cell carcinoma (OSCC). SET and MYND domain-containing protein 3 (SMYD3), a histone lysine methyltransferase, is implicated in gene transcription regulation and tumor development. However, the roles of SMY...

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Автори: Zongcheng Yang, Fen Liu, Zongkai Li, Nianping Liu, Xinfeng Yao, Yu Zhou, Liyu Zhang, Pan Jiang, Honghong Liu, Lingming Kong, Chuandong Lang, Xin Xu, Jihui Jia, Takahito Nakajima, Wenchao Gu, Lixin Zheng, Zhihong Zhang
Формат: Artigo
Мова:Inglês
Опубліковано: BMC 2023-05-01
Серія:Clinical Epigenetics
Предмети:
Oral squamous cell carcinoma
Tumorigenesis
Epigenetics
SMYD3
HMGA2
Онлайн доступ:https://doi.org/10.1186/s13148-023-01506-9
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