PI3Kdelta-driven expansion of regulatory B cells impairs protective immune responses to Trypanosoma congolense parasite infection.

Phosphatidylinositol 3-kinase delta (PI3KCD) is a critical signaling enzyme for B cell development, activation, function and immune regulation. Gain-of-function mutations in PI3KCD result in the congenital immunodeficiency known as Activated PI3KCD Syndrome (APDS). APDS patients are prone to repeate...

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Hauptverfasser:	Folayemi Olayinka-Adefemi, Xun Wu, Sen Hou, Milad Sabzevary-Ghahfarokhi, Michelle N Wray-Dutra, David J Rawlings, Jude Uzonna, Aaron J Marshall
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2025-11-01
Schriftenreihe:	PLoS Pathogens
Online-Zugang:	https://doi.org/10.1371/journal.ppat.1013663
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