PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma

Abstract Background Alpha-fetoprotein (AFP) is a key biomarker for hepatocellular carcinoma (HCC), but 30–40% of cases are AFP-negative. Prothrombin induced by vitamin K absence II (PIVKA-II) is more sensitive for HCC detection, though its role in systemic therapy remains underexplored. This study a...

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Bibliografiske detaljer

Principais autores:	San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2025-02-01
Serier:	BMC Cancer
Fag:	PIVKA-II Des-γ-carbonylated prothrombin (DCP) Alpha-fetoprotein (AFP) Hepatocellular carcinoma (HCC) Biomarker
Online adgang:	https://doi.org/10.1186/s12885-025-13568-4
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