Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-<i>a</i>]Pyrimidines as New Acetylcholinesterase Inhibitors

A new series of thiazolo[3,2-<i>a</i>]pyrimidine bromide salt derivatives <b>7a</b>&#8722;<b>d</b> were synthesized from 3,4-dihydropyrimidinethione precursors. The target compounds were fully characterized by 1D- and 2D-NMR, high resolution ESI-MS/MS and single crystal X-ray diffraction analysis, w...

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Auteurs principaux:	Mohamed Y. Mahgoub, Awatef M. Elmaghraby, Abd-Elfttah A. Harb, João L. Ferreira da Silva, Gonçalo C. Justino, M. Matilde Marques
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2019-06-01
Collection:	Molecules
Sujets:	thiazolopyrimidines acetylcholinesterase inhibition molecular docking crystal structures
Accès en ligne:	https://www.mdpi.com/1420-3049/24/12/2306
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