Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas

Mechanistic target of rapamycin (mTOR) complex 1 is a central integrator of nutrient and growth factor inputs that controls cell growth in eukaryotes. The second generation of mTOR kinase inhibitors (TORKi), directly targeting the mTOR catalytic site, are more effective than rapamycin and its analog...

Полное описание

Библиографические подробности

Главные авторы:	Chengfeng Bi, Xuan Zhang, Ting Lu, Xiaoyan Zhang, Xianhuo Wang, Bin Meng, Huilai Zhang, Ping Wang, Julie M. Vose, Wing C. Chan, Timothy W. McKeithan, Kai Fu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Ferrata Storti Foundation 2017-04-01
Серии:	Haematologica
Online-ссылка:	https://haematologica.org/article/view/8041
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