Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity

Abstract DNA derived from chemotherapeutics-killed tumor cells is one of the most important damage-associated molecular patterns that can activate the cGAS-STING (cyclic GMP-AMP synthase—stimulator of interferon genes) pathway in antigen-presenting cells (APCs) and promote antitumor immunity. Howeve...

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Autors principals:	Chaoyu Wang, Ruoshi Zhang, Jia He, Lvshan Yu, Xinyan Li, Junxia Zhang, Sai Li, Conggang Zhang, Jonathan C. Kagan, Jeffrey M. Karp, Rui Kuai
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2023-06-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-023-39607-x
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