Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD

Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by metabolic dysfunction and inflammation burden, involving a significant enhancement of cellular glycolytic activity. Here, we elucidate how a positive feedback loop in liver macrophages drives MASLD pathogen...

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Principais autores:	Jinyang Li, Xiancheng Chen, Shiyu Song, Wangjie Jiang, Tianjiao Geng, Tiantian Wang, Yan Xu, Yongqiang Zhu, Jun Lu, Yongxiang Xia, Rong Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-03-01
Series:	Cell Reports
Assuntos:	CP: Metabolism CP: Immunology
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124725001214
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