Sugar coating autophagy: exploring the links between the inhibition of NGLY1 (N-glycanase 1) and autophagy induction

The cytosolic enzyme NGLY1 (N-glycanase 1) is a central mediator of glycoprotein catabolism. The enzyme acts to cleave N-linked glycans from modified substrate asparagine residues prior to degradation of misfolded proteins by the proteasome, playing a key and well-conserved role in the ER-associated...

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Detalles Bibliográficos

Autores principales:	Holger B. R. Kramer, Sarah Ann Allman
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2023-12-01
Colección:	Autophagy Reports
Materias:	autophagy autophagy induction caspase inhibition erad glycoprotein catabolism ngly1 peptide:n-glycanase z-vad-fmk
Acceso en línea:	http://dx.doi.org/10.1080/27694127.2023.2166324
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