Epidermal Growth Factor Receptor Inhibition Reverses Cellular and Transcriptomic Alterations Induced by Hypoxia in the Neonatal Piglet Brain

Summary: Acute hypoxia (HX) causes extensive cellular damage in the developing human cerebral cortex. We found increased expression of activated-EGFR in affected cortical areas of neonates with HX and investigated its functional role in the piglet, which displays a highly evolved, gyrencephalic brai...

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Main Authors:	Panagiotis Kratimenos, Evan Z. Goldstein, Ioannis Koutroulis, Susan Knoblach, Beata Jablonska, Payal Banerjee, Shadi N. Malaeb, Surajit Bhattacharya, M. Isabel Almira-Suarez, Vittorio Gallo, Maria Delivoria-Papadopoulos
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2020-12-01
Series:	iScience
Subjects:	Porcine Molecular Biology Developmental Neuroscience Transcriptomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004220309639
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