Glycines from the APP GXXXG/GXXXA transmembrane motifs promote formation of pathogenic Aβ oligomers in cells

Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by progressive cognitive decline leading to dementia. The amyloid precursor protein (APP) is a ubiquitous type I transmembrane (TM) protein sequentially processed to generate the β-amyloid peptide (Aβ), the major co...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Marie eDecock, Serena eStanga, Jean-Noël eOctave, Ilse eDewachter, Steven O Smith, Stefan N Constantinescu, Pascal eKienlen-Campard
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2016-05-01
Цуврал:	Frontiers in Aging Neuroscience
Нөхцлүүд:	oligomers Alzheimer’s disease amyloid precursor protein neuronal differentiation Beta-amyloid peptide GXXXG motifs
Онлайн хандалт:	http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00107/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!