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Dual oncogenic role of RNF220 in AML: linking metabolic rewiring to cell proliferation and immune evasion

BackgroundAcute myeloid leukemia (AML) remains a clinical challenge with suboptimal long-term survival. While circular RNAs derived from the RNF220 host gene have been implicated in AML pathogenesis, the functional role and regulatory mechanisms of RNF220 itself in AML are poorly understood.MethodsW...

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Principais autores: Bixia Li, Shi Jiang, Yao Xu, Xiao Yan, Qitian Mu, Guifang Ouyang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-10-01
coleção:Frontiers in Oncology
Assuntos:
acute myeloid leukemia
RNF220
tumor metabolism
tumor microenvironment
immune evasion
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2025.1670895/full
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