RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analysis of...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Adam Labadorf, Andrew G Hoss, Valentina Lagomarsino, Jeanne C Latourelle, Tiffany C Hadzi, Joli Bregu, Marcy E MacDonald, James F Gusella, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Richard H Myers
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2015-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	http://europepmc.org/articles/PMC4670106?pdf=render
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