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Toxic epidermal necrolysis [version 1; referees: 3 approved]

Toxic epidermal necrolysis (TEN) is a rare, life-threatening drug-induced skin disease with a mortality rate of approximately 30%. The clinical hallmark of TEN is a marked skin detachment caused by extensive keratinocyte cell death associated with mucosal involvement. The exact pathogenic mechanism...

Celý popis

Uloženo v:
Hlavní autoři: Wolfram Hoetzenecker, Tarun Mehra, Ieva Saulite, Martin Glatz, Peter Schmid-Grendelmeier, Emmanuella Guenova, Antonio Cozzio, Lars E. French
Médium: Artigo
Jazyk:Inglês
Vydáno: F1000 Research Ltd 2016-05-01
Edice:F1000Research
Témata:
Allergy & Hypersensitivity
Dermatologic Pathology
Dermatologic Pharmacology
Drug Eruptions
Immune Response
Immunopharmacology & Hematologic Pharmacology
Innate Immunity
Leukocyte Activation
Leukocyte Signaling & Gene Expression
Toxicology
On-line přístup:http://f1000research.com/articles/5-951/v1
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