A computational framework for sensitive tumor detection and accurate subtyping using shallow cell-free DNA methylome sequencing

Abstract Plasma circulating tumor DNA (ctDNA) enables non-invasive monitoring of metastatic cancer. However, the detection of low tumor content (TC) via tumor tissue-agnostic approaches remains challenging. We introduce METER, a computational strategy exploiting tumor-type specific DNA methylation p...

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Egile Nagusiak:	Marta Paoli, Francesca Galardi, Agostina Nardone, Chiara Biagioni, Dario Romagnoli, Samantha Di Donato, Gian Marco Franceschini, Luca Livraghi, Marta Pestrin, Giuseppina Sanna, Emanuela Risi, Ilenia Migliaccio, Erica Moretti, Luca Malorni, Laura Biganzoli, Francesca Demichelis, Matteo Benelli
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2026-02-01
Saila:	Genome Medicine
Gaiak:	Liquid biopsy DNA methylation Circulating tumor DNA Biomarker Methylome Breast cancer
Sarrera elektronikoa:	https://doi.org/10.1186/s13073-026-01603-3
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