CPT2 inhibition enhances selective autophagy and proliferation in colorectal cancer via GPAT4-dependent glycerophospholipid biosynthesis

Abstract Metabolic reprogramming is one of the hallmark events in colorectal cancer. Tumor cells adapt to microenvironmental changes by regulating energy and biomaterial metabolism. This study identifys abnormal lipid accumulation and significant downregulation of fatty acid metabolism in colorectal...

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Detalhes bibliográficos

Principais autores:	Kuo Li, Hongyan Wang, Chan Li, Mingming Xiao, Yuan Luo, Shikai Shen, Guosheng Li, Yuan Fu, Wenbin Chen, Ruofan Shao, Wanlin Cui, Hongfu Wei, Jingyang Zhao, Mengfei Liu, Juan Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-10-01
coleção:	Communications Biology
Acesso em linha:	https://doi.org/10.1038/s42003-025-08877-0
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