Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has shown unprecedented success in haematological cancers but faces challenges in solid tumours. Although carcinoembryonic antigen‐related cell adhesion molecule 5 (CEACAM5) is differentially expressed in many solid tumours, anti‐CEACAM5 CAR T‐...

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Detalhes bibliográficos

Principais autores:	Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-03-01
coleção:	Advanced Science
Assuntos:	CAR T cell CEACAM5 CRC enzyme glycocalyx
Acesso em linha:	https://doi.org/10.1002/advs.202509762
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