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cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity

Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus that causes great economic losses globally to the swine industry. Innate immune RNA receptors mainly sense it during infection. As a DNA sensor, cyclic GMP-AMP synthase (cGAS) plays an important role in sensing cytosolic DNA...

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Principais autores: Xiao-Na Liu, Li-Wei Li, Fei Gao, Yi-Feng Jiang, Wan-Zhe Yuan, Guo-Xin Li, Ling-Xue Yu, Yan-Jun Zhou, Guang-Zhi Tong, Kuan Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
coleção:Frontiers in Immunology
Assuntos:
PRRSV
cGAS
mtDNA
cGAMP
replication
antiviral activity
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.887054/full
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