Klotho protein alleviates heart ischemia/reperfusion injury and oxidative stress through regulation of the NOS/MMP pathway
Abstract Heart ischemia/reperfusion injury (IRI) significantly contributes to cardiac damage through oxidative and nitrosative stress, where the dysregulation of nitric oxide synthases (NOS) and the subsequent activation of matrix metalloproteinases (MMPs) are observed. Klotho is a multifunctional p...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2025-09-01
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| Series: | Scientific Reports |
| Acceso en liña: | https://doi.org/10.1038/s41598-025-18021-x |
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