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Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers

The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target. Radiotherapy innovations such as stereotactic body radiotherapy herald new opportunities for classical oxygen-...

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Principais autores: Lydia P. Liew, Avik Shome, Way W. Wong, Cho R. Hong, Kevin O. Hicks, Stephen M. F. Jamieson, Michael P. Hay
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-05-01
Serier:Molecules
Fag:
chemoradiotherapy
DNA damage
electron affinity
hypoxia
nitroimidazole
prodrugs
Online adgang:https://www.mdpi.com/1420-3049/28/11/4457
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