Polymerase θ inhibition steps on the cGAS pedal
Deficiencies in homologous recombination (HR) repair lead to an accumulation of DNA damage and can predispose individuals to cancer. Polymerase theta (Pol θ, encoded by POLQ) is overexpressed by HR-deficient cancers and promotes cancer cell survival by mediating error-prone double-stranded break (DS...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2023-06-01
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| Serie: | The Journal of Clinical Investigation |
| Accesso online: | https://doi.org/10.1172/JCI170660 |
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