A QM/MM–Based Computational Investigation on the Catalytic Mechanism of Saccharopine Reductase

Saccharopine reductase from Magnaporthe grisea, an NADPH-containing enzyme in the α-aminoadipate pathway, catalyses the formation of saccharopine, a precursor to L-lysine, from the substrates glutamate and α-aminoadipate-δ-semialdehyde. Its catalytic mechanism has been investigated using quantum mec...

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Hlavní autoři:	James W. Gauld, Eric A.C. Bushnell, Joel N. Almasi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2011-10-01
Edice:	Molecules
Témata:	Schiff base saccharopine reductase α-aminoadipate-δ-semialdehyde saccharopine imine formation carbinolamine QM/MM theoretical computational
On-line přístup:	http://www.mdpi.com/1420-3049/16/10/8569/
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