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Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients

Abstract Background Age-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “inflammaging” and is implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD). Whether changes in the tissue environment caused by circulatory factors...

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Principais autores: Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma, Julian Hellmann-Regen
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2023-10-01
Series:Immunity & Ageing
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Acceso en liña:https://doi.org/10.1186/s12979-023-00376-2
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