RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity

Abstract The cellular plasticity of neuroblastoma is defined by a mixture of two major cell states, adrenergic and mesenchymal, which may contribute to therapy resistance. However, how neuroblastoma cells switch cellular states during therapy remains largely unknown, and how to eradicate neuroblasto...

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Autores principales:	Shivendra Singh, Jie Fang, Hongjian Jin, Lee-Ann Van De Velde, Andrew Cortes, Jiani Chen, Sivaraman Natarajan, Evon Poon, Qiong Wu, Christopher L. Morton, Mary A. Woolard, Waise Quarni, Jacob A. Steele, Jon P. Connelly, Liusheng He, Rebecca Thorne, Gregory Turner, Thomas Confer, Melissa Johnson, William V. Caufield, Burgess B. Freeman, Timothy Lockey, Andrew J. Murphy, Peter J. Murray, Takashi Owa, Shondra M. Pruett-Miller, Ruoning Wang, Louis Chesler, Julie R. Park, Andrew M. Davidoff, John Easton, Xiang Chen, Paul G. Thomas, Jun Yang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-09-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-025-63979-x
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