Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set

Abstract Human plasma is routinely collected during clinical care and constitutes a rich source of biomarkers for diagnostics and patient stratification. Liquid chromatography-mass spectrometry (LC-MS)-based proteomics is a key method for plasma biomarker discovery, but the high dynamic range of pla...

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Principais autores:	Ute Distler, Han Byul Yoo, Oliver Kardell, Dana Hein, Malte Sielaff, Marian Scherer, Anna M. Jozefowicz, Christian Leps, David Gomez-Zepeda, Christine von Toerne, Juliane Merl-Pham, Teresa K. Barth, Johanna Tüshaus, Pieter Giesbertz, Torsten Müller, Georg Kliewer, Karim Aljakouch, Barbara Helm, Henry Unger, Dario L. Frey, Dominic Helm, Luisa Schwarzmüller, Oliver Popp, Di Qin, Susanne I. Wudy, Ludwig Roman Sinn, Julia Mergner, Christina Ludwig, Axel Imhof, Bernhard Kuster, Stefan F. Lichtenthaler, Jeroen Krijgsveld, Ursula Klingmüller, Philipp Mertins, Fabian Coscia, Markus Ralser, Michael Mülleder, Stefanie M. Hauck, Stefan Tenzer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-10-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-64501-z
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