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Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells

Summary: Long-term culture of primary cells is characterized by functional and secretory changes, which ultimately result in replicative senescence. It is largely unclear how the metabolome of cells changes during replicative senescence and if such changes are consistent across different cell types....

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Principais autores: Eduardo Fernandez-Rebollo, Julia Franzen, Roman Goetzke, Jonathan Hollmann, Alina Ostrowska, Matteo Oliverio, Torsten Sieben, Björn Rath, Jan-Wilhelm Kornfeld, Wolfgang Wagner
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-02-01
coleção:Stem Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213671119304515
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