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Cerebrospinal fluid ctDNA clarifies clonal divergence: leptomeningeal flare of EGFR-mutant disease after switch to selpercatinib for acquired RET fusion

Liquid biopsy can expose spatially segregated resistance biology that is invisible to single-site tissue testing, particularly across the blood–brain barrier. We report how cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) clarified therapeutic direction in EGFR-mutated non-small-cell lung can...

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Principais autores: Kei Kunimasa, Motohiro Tamiya, Takako Inoue, Nobuaki Mamesaya, Tsunehiro Tanaka, Kiyohide Komuta, Shun Futamura, Keiichiro Honma, Kazumi Nishino
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-12-01
coleção:The Journal of Liquid Biopsy
Assuntos:
Cerebrospinal fluid
Circulating tumor DNA
Leptomeningeal metastasis
RET fusion
Clonal divergence
EGFR exon 19 deletion
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2950195425001675
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