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A central role for fibrinogen in promoting microglial repair of the hypoxia-disrupted blood-brain barrier

Abstract Building on our previous finding that a small fibrinogen peptide inhibits microglial repair of the hypoxia-disrupted blood-brain barrier (BBB), we directly evaluated the importance of fibrinogen in this process by studying these events in fibrinogen knockout (KO) mice. While young (4 months...

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Principais autores: Sebok K. Halder, Arjun Sapkota, Richard Milner
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Journal of Neuroinflammation
Fag:
Brain
Blood vessels
Fibrinogen
Microglia
Mac-1 integrin
Chronic mild hypoxia
Online adgang:https://doi.org/10.1186/s12974-026-03759-6
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