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KPNB1 mediates PER/CRY nuclear translocation and circadian clock function

Regulated nuclear translocation of the PER/CRY repressor complex is critical for negative feedback regulation of the circadian clock of mammals. However, the precise molecular mechanism is not fully understood. Here, we report that KPNB1, an importin β component of the ncRNA repressor of nuclear fac...

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Main Authors: Yool Lee, A Reum Jang, Lauren J Francey, Amita Sehgal, John B Hogenesch
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
KPNB1
PER
CRY
nuclear entry
circadian clock
Online Access:https://elifesciences.org/articles/08647
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