Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adultsResearch in context

Summary: Background: Viperidae snakes are responsible for many of the 94,000 deaths caused by snakebite envenoming each year. The most pathological venom component of this globally diverse family of snakes are the zinc-dependent snake venom metalloproteinase (SVMP) enzymes, which can be inhibited b...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Michael Abouyannis, Yvonne K. Nyambura, Samson Ngome, Debra Riako, Jennifer Musyoki, Charles Muiruri, Benedict Orindi, Laura Else, Alieu Amara, Laura Dickinson, Rachel H. Clare, Laura-Oana Albulescu, Adam P. Westhorpe, Jeroen Kool, Ifedayo Adetifa, Francis M. Ndungu, Richard FitzGerald, Saye Khoo, David G. Lalloo, Nicholas R. Casewell, Mainga Hamaluba
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-03-01
coleção:	EBioMedicine
Assuntos:	Phase 1 clinical trial Snakebite Envenoming Unithiol
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352396425000441
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!